Quantitative assessment of CD79B depletion as a biomarker of accelerated B cell progenitor aging
Year: 2026
Type: article
Abstract: We previously demonstrated that age-related dysfunction in lipid synthesis pathways is associated with impaired B cell progenitor development in mice and humans. Here, we describe an optimized protocol for the quantification of CD79B, a novel biomarker of accelerated aging identified in our multi-omics immune aging study. Flow cytometric analyses of immune cell subpopulations revealed selective depletion of CD19 + CD79B + lymphoid progenitors in bone marrow from aged mice and accelerated aging models, phenocopying advanced physiological aging in humans. Thus, this detailed protocol provides a validated platform to interrogate novel biomarkers of hematopoietic stem and progenitor cell dysfunction associated with systemic aging
Source: Stem Cell Research
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,360
Funders: California Institute for Regenerative Medicine, American Society of Hematology, International Waldenstrom's Macroglobulinemia Foundation, Research to Prevent Blindness, International Myeloma Foundation, Leukemia and Lymphoma Society, National Institutes of Health, University of California, San Diego, University of California, Irvine, National Eye Institute, National Cancer Institute
OpenAlex ID: W7155105050