Work

Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

Year: 2026

Type: article

Abstract: This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 gene (c.3343G> A: p.Val1115Ile). Despite optimal medical therapy and implantable cardioverter-defibrillator (ICD) implantation, the patient developed progressive cardiac dysfunction and recurrent ICD shocks. We discuss the clinical course, genetic findings, and imaging features of this case.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2026.1753832

Authors: Ying Li, Na Jia, Xinyue Li, Jingwen Dai, Deping Liu

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking University, Beijing Hospital

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801