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Automated red cell exchange in acute sickle cell crises: Case series and review of the literature

Year: 2026

Type: article

Abstract: Automated red cell exchange (erythrocytapheresis) offers rapid suppression of circulating hemoglobin S without adding iron burden and is increasingly used to escalate care in acute sickle cell disease complications. This study describes four patients with severe vaso-occlusive crisis and/or acute chest syndrome managed with automated red cell exchange in a tertiary-care intensive care unit in India and summarizes Indian reports on its feasibility and on early outcomes. In the Indian scenario, this therapy is underutilized mostly due to the limited-resource setting, non-affordability, and probable lack of awareness of its availability.

Source: Hematology Transfusion and Cell Therapy

DOI: 10.1016/j.htct.2026.106454

Authors: V. Aishwarya, Soumya Das, Juilee Shalik Charmode, Parag Fulzele, Rounak Dubey, Neema Vijay

Institution: All India Institute of Medical Sciences, Nagpur

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7155158045

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Cites: 9

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