Mechanochemically Driven Synthesis of Anticancer Cocrystals: A Case Study of Lenalidomide
Year: 2026
Type: article
Abstract: The modulation of physicochemical properties through the discovery of new solid forms has attracted significant interest in the pharmaceutical industry. Herein, a novel cocrystal of lenalidomide with quercetin was designed upon crystal engineering principles. Bearing in mind the importance of developing sustainable methods for the pharmaceutical industry, the synthesis of the novel cocrystals was explored by different mechanochemical approaches and slurry techniques for comparison purposes. Thus, the cocrystal was produced by liquid‐assisted grinding in ball milling, liquid‐assisted resonant acoustic mixing, and the slurry method. All the methods yielded the same final form with similar properties. From the point of view of properties enhancement, solubility studies showed that the cocrystal exhibited lower solubility than that of pure lenalidomide under simulated conditions of gastric and intestinal fluids, suggesting that the cocrystal may function as an extended‐release form of lenalidomide. Furthermore, this cocrystal remained stable under accelerated stability conditions, indicating that atmospheric relative humidity does not represent a risk for the handling or storage of these compounds in the solid state.
Source: Chemistry - Methods
DOI: 10.1002/cmtd.70092
Institutions: University of Lisbon, Instituto Superior Técnico, IST-ID - Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Centro de Química Estrutural, LAQV Requimte, Laboratório de Análises LAQV-REQUIMTE, Universidade Nova de Lisboa, Universidade do Porto, Rede de Química e Tecnologia, University of Parma, Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, UCLouvain, Trinity College Dublin, École Nationale Supérieure de Chimie de Montpellier, Centre National de la Recherche Scientifique, Institut Charles Gerhardt Montpellier
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,750
Awards: G1728218751, G2346795057, G2454277087, G2470611001, G2513733463, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G2578531282, G2756637201, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G2854505947, Innovative Mechanochemical Processes to synthesize green ACTIVE pharmaceutical ingredients., G3153136353, Instituto de Ciências Moleculares, G332082475, G3692802076, G4342814924, Centro de Química Estrutural, G4693354510, G4721828077, G4827025924, Centro de Química Estrutural, G4971484151, G5089812422, G5371781880, Centro de Química Estrutural, G5624307780, G5840578314, G5868090805, G6219246445, G6360913918, G6563235921, G6875380692, G6997658380, G7148304117, G7236559868, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G7452604077, G7501588509, G7961091540, G8214220107, G8492102835, G85722789
OpenAlex ID: W7155158308