Neurological Puzzles After Radiotherapy: Mysterious Clues of Smart Syndrome, Two Case Reports
Year: 2026
Type: article
Study design: Case Report
Abstract: SMART (stroke-like migraine attacks after radiation therapy) syndrome is a rare neurological disorder characterized by stroke-like symptoms and migraine-like headaches years after brain radiotherapy. Its pathophysiology remains unclear but is linked to vascular damage, inflammation, and mitochondrial dysfunction. This study presents two cases, emphasizing clinical and radiological findings. MRI is crucial for diagnosis, often showing transient cortical hyperintensities and contrast enhancement. Misdiagnosis as stroke or tumor recurrence may lead to unnecessary interventions. Increasing awareness is essential for accurate diagnosis and management. Further research is needed to refine diagnostic criteria and optimize treatment strategies for this rare but significant condition.
Source: Journal of Clinical Ultrasound
DOI: 10.1002/jcu.70257
Institution: Selçuk University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7155165102