Work

Analysis of influencing factors for postoperative prognosis of patients with knee osteoarthritis

Year: 2026

Type: article

Abstract: Objective To analyze the influencing factors of postoperative prognosis in patients with knee osteoarthritis (KOA) and to construct and validate a Nomogram prediction model. Methods A total of 260 patients who underwent KOA surgical treatment and were admitted between January 2021 and May 2023 were selected. The patients were divided into a training set ( n = 182) and a validation set ( n = 78) in a ratio of 7:3 by the complete randomization method. Relevant factors influencing postoperative prognosis were screened out through univariate analysis and multivariate logistic regression analysis. A Nomogram prediction model was constructed, and the model was validated and evaluated using the concordance index (C-index), calibration curve, and decision curve analysis (DCA). Results The results of the multivariate logistic regression analysis showed that VAS score, ROM, time to first ambulation after surgery, CRP, erythrocyte sedimentation rate, IL-6, and knee circumference were independent influencing factors affecting postoperative prognosis (all P < 0.05). The receiver operating characteristic curves showed that in the training set and the validation set, the area under the curves of the Nomogram model for predicting poor prognosis after KOA surgery were 0.938 (95% CI: 0.871–1.000) and 0.873 (95% CI: 0.806–0.941), respectively, and the sensitivities and specificities were 0.786, 0.925 and 0.718, 0.933, respectively. The constructed Nomogram prediction model had good discrimination. The calibration curve showed good consistency, and DCA analysis indicated that the model had clinical application value. Conclusion VAS score, ROM, time to first ambulation after surgery, CRP, erythrocyte sedimentation rate, IL-6, and knee circumference affect the postoperative prognosis of KOA. The constructed Nomogram prediction model has high accuracy and clinical application value.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1686941

Authors: Zemiao Liu, Deheng Liu

Institutions: Shandong University, Qilu Hospital of Shandong University

Language: English

Topic: Total Knee Arthroplasty Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801