Work

A study on the structural and magnetic properties of Fe 3 O 4 @SiO 2 core-shell microspheres along with a safety assessment in treating chemotherapy-resistant ovarian cancer

Year: 2026

Type: article

Abstract: Background Ovarian cancer (OC) presents a significant challenge in the medical field due to its high mortality and resistance to chemotherapy. Chemoresistance in OC diminishes treatment efficacy and contributes to poor patient outcomes. Magnetic hyperthermia (MH) has demonstrated potential for addressing the chemoresistance of ovarian cancer (OC) directly through thermal effects.Methods The coprecipitation method was used to produce Fe3O4 MNPs. Using a modified Stöber approach, the core-shell Fe3O4@SiO2 MNPs were produced. Transcriptome sequencing was employed to evaluate the safety of Fe3O4@SiO2 nanoparticles and to investigate the underlying mechanism of magnetic hyperthermia. An animal subcutaneous xenograft model was used to investigate the safety and efficacy of magnetic fluid therapy under magnetic hyperthermia.Results The Fe3O4@SiO2 magnetic fluid was successfully synthesized and several characterization experiments confirmed its good dispersion and magnetic properties. The target temperature of 50 °C can be reached within 5 min in the magnetic induction coil, and can be maintained at the target temperature for the subsequent time. Preclinical trials (animal model) validated MH’s biocompatibility and tumor suppression capacity.Conclusion Core-shell structured Fe3O4@SiO2 nanocomposites were fabricated through coprecipitation method and a modified Stöber approach, demonstrating monodisperse morphology and enhanced colloidal stability for biomedical applications. Both in vitro and in vivo experiments have confirmed that the magnetic fluid has good safety and excellent therapeutic effect under the magnetic induction coil.

Source: International Journal of Hyperthermia

DOI: 10.1080/02656736.2025.2610818