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Probable pyoderma gangrenosum complicated with cutaneous Aspergillus flavus infection: case report

Year: 2026

Type: article

Abstract: Pyoderma gangrenosum (PG) is a rare, chronic, autoinflammatory neutrophilic dermatosis. Its typical clinical manifestations include painful papules and pustules surrounded by erythema on the lower extremities and trunk, which gradually progress to form well-demarcated, painful ulcers with undermined edges. Due to impaired skin barrier function, prolonged wound exposure, and the frequent need for immunosuppressive therapy, PG patients are highly susceptible to secondary infections. We report here a clinical case of successful treatment with glucocorticoids and voriconazole, combined with multiple sessions of negative-pressure wound therapy and skin grafting, in a patient with cutaneous Aspergillus flavus infection and possible pyoderma gangrenosum.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1806433

Authors: Shaoqin Sun, Mengting Zhu, Changhui Wen

Institution: Guizhou University

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801