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Beyond Chronological Age: Gender, Inflammation and Cytomegalovirus Shape Innate Immune Cell Profiles in Sicilian Centenarians, Semi-supercentenarians, and Supercentenarians

Year: 2026

Type: article

Abstract: Our findings suggest that the reported associations between age and increased NK cell and monocyte counts may largely reflect indirect effects mediated by sex (for NK cells) and systemic inflammation, as indicated by IL-6 levels (for monocytes), rather than a direct consequence of chronological ageing per se.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.19698726

Authors: BERTOLAZZI, Giorgio, Calabrò, Anna, MERAVIGLIA, Serena, Caruso, Calogero

Institutions: Università degli Studi di Enna Kore, University of Palermo, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7155171305

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