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Novel Macrocyclic Compounds Targeting STING for Autoimmune Diseases Treatment

Year: 2026

Type: editorial

Abstract: This patent demonstrates a series of macrocycle-based compounds that antagonize stimulator of interferon genes (STING), a key role in the innate immune response implicated in autoimmune diseases. These compounds, along with their pharmaceutically acceptable salt thereof, are intended for the treatment of autoimmune related diseases driven by STING-mediated pathways.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00191

Authors: Yanwei Jiang, Steven H. Liang

Institutions: Emory University, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7155175975

Cites: 6

Cited by: 1

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