Work

Autoimmune nodopathy and focal segmental glomerulosclerosis mediated by anti-NF186 antibody: a case report and literature review

Year: 2026

Type: article

Abstract: BACKGROUND: Focal segmental glomerulosclerosis (FSGS) and autoimmune nodopathy (AN) exhibit specific associations with anti-NF186 antibodies, which may act as circulating factors contributing to the development of both conditions. However, these cases are very rare, and the underlying pathogenesis mechanisms remain unclear. CASE PRESENTATION: Here, we report a 63-year-old male patient presented with concurrent FSGS and AN, tested positive for anti-NF186 antibodies. Following the administration of plasma exchange and corticosteroid therapy, both neuropathy and nephropathy exhibited significant improvement. He has achieved a favorable outcome following a seven-month of corticosteroid treatment. CONCLUSIONS: This case highlights that acute onset quadriparesis with respiratory involvement may be observed in concurrent AN and FSGS mediated by anti-NF186 antibodies, suggesting a close association of these symptoms.

Source: BMC Neurology

DOI: 10.1186/s12883-026-04917-2

Authors: Yang Zhang, Naijuan Yao, Jie Yang, Yurong Zou, Ping Zhang, Yunlin Feng

Institutions: University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090