Noncalcined Bioactive Glass/Fish Scale Gelatin Hybrids Prepared by Sol–Gel Processing for Enhanced In Vitro Bioactivity
Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Fish-derived biomaterials have attracted increasing interest for biomedical applications due to their biocompatibility and sustainability. In this study, fish scale gelatin was extracted through sequential acid-alkaline treatment followed by heat extraction at 75 °C and utilized to fabricate a composite scaffold with bioactive glass (BG). BG sol was synthesized from tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, nitric acid, ethanol, and deionized water using a sol–gel method. The BG sol was blended with fish scale gelatin solution and stirred for 2 days to form a wet gel, which was subsequently oven-dried for 6 h to obtain fish scale gelatin/bioactive glass (FSG/BG) composites. The materials were characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy with energy-dispersive X-ray (SEM-EDX), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Thermal analyses showed that the extracted gelatin exhibited behavior comparable to commercial gelatin. FTIR spectra confirmed the formation of Si–O–Si networks and the presence of characteristic protein functional groups in the composite. The compressive strength of the FSG/BG scaffold (7.63 MPa) was higher than that of pure BG (6.51 MPa), indicating improved structural integrity. In vitro bioactivity was evaluated by immersing BG and FSG/BG discs in simulated body fluid (SBF) at 37.5 ± 0.5 °C for up to 16 days. Hydroxyapatite formation on the scaffold surface and Ca 2+ concentration changes confirmed the favorable apatite-forming ability and bioactivity of the FSG/BG composite, suggesting its potential for bone tissue engineering applications.
Source: ACS Omega
Institution: Silpakorn University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W7155182271