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Novel 1-Phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives as Na v 1.8 Voltage-Gated Sodium Channels Inhibitors

Year: 2026

Type: editorial

Abstract: High Resolution Image Download MS PowerPoint Slide This highlight outlines the development of novel substituted 1-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives as potential inhibitor candidates for Na v 1.8 voltage-gated sodium channels (Na v 1.8), which is upregulated or activated to transmit nociceptive signaling in a range of pain-related disorders. The invention includes details on preparation methods, biological activity assays, and pharmaceutical compositions.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00189

Authors: Ruihu Song, Steven H. Liang

Institutions: Emory University, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7155186535

Cites: 8

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