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Iron Porphyrin Catalysts Induce Stereospecific Glycosylation with Glycal Epoxides

Year: 2026

Type: article

Abstract: This account highlights an iron porphyrin-catalyzed highly stereospecific glycosylation method for glycal epoxides. This method is effective for a wide variety of previously challenging, hindered secondary sugar acceptors and a broad array of both electron-rich and electron-deficient glycal epoxide donors. It plays a pivot role in stereoselective heparan sulfate oligosaccharide synthesis, and the kinetic studies revealed that this glycosylation proceeds through SN2-type pathways with both primary and hindered secondary acceptors.

Source: Synlett

DOI: 10.1055/a-2861-7444