A case report of thoracic SMARCA4-deficient undifferentiated tumor associated with brain metastases
Year: 2026
Type: article
Study design: Case Report
Abstract: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) were considered distinct from the traditional NSCLC with SMARCA4-deficient (SMARCA4-dNSCLC) in the 5th edition of the WHO classification of thoracic tumors in 2021. Due to the low incidence rate and the lack of sufficient research, clear treatment guidelines for SMARCA4-UT are currently lacking. We report a rare case of thoracic SMARCA4-deficient undifferentiated tumor with multiple brain metastases. Following treatment with cranial metastasis radiotherapy and systemic immunotherapy combined with chemotherapy, the lesions significantly decreased in size, and the patient's symptoms improved markedly. This article retrospectively analyzed the diagnosis and treatment process of a case of SMARCA4-UT and discussed therapeutic progress and future prospects. Given the limitations of current single-drug therapy, the combined use of immunotherapy, chemotherapy, and new target drugs is an essential choice and the future direction.
Source: Frontiers in Oncology
Authors: Min Yang, Yang Wang, Xiaolong Fang, Yuntao Wang, Qingliang Xu, Chunyan Tang, Li Qi, Aijie Li, Jingjing Li
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7155189869