Work

Proximal TGF-β Signaling in Chronic Injury: from a notorious fibrotic factor to a repair ally

Year: 2026

Type: article

Abstract: Transforming growth factor beta (TGF-β) is a pleiotropic factor that plays a key role in the pathophysiology of chronic kidney disease (CKD). However, targeting TGF-β inhibition failed to mitigate CKD in practice. The proximal tubule (PT), the most vulnerable renal segment, plays a central role in post-injury repair or the drift to CKD. Despite its well-documented profibrotic effects, recent studies revealed benefits of TGF-β signaling in PT response to CKD, raising the question of its therapeutic potential. This review highlights mechanisms by which TGF-β signaling mediates the PT adaptive response to chronic injury and provides perspectives for developing novel CKD therapy.

Source: Pflügers Archiv - European Journal of Physiology

DOI: 10.1007/s00424-026-03168-x

Author: Stellor Nlandu Khodo

Institutions: Inserm, University of Zurich, Sorbonne Université, Hôpital Tenon

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,390