Short Peptide with Sequence of LAGAAHF, Identified from Edible Bird’s Nest, Reduces Dermatitis Symptoms in Mice
Year: 2026
Type: article
Abstract: Background/Objectives: Native to the Indo-Pacific region, edible bird’s nests (EBN; Yan Wo in Chinese) are the solidified saliva of swiftlets (Aerodramus fuciphagus and A. maximus) and have been consumed as a traditional functional food for centuries. However, the bioactive components and underlying mechanisms of EBN remain poorly understood. EBN consists of over 60% protein, much of which is heavily glycosylated, forming complex glycoconjugates that are resistant to enzymatic digestion. This study examines the properties of EBN-derived bioactive peptides and assesses their potential for skin moisturization and anti-inflammation when applied topically. Methods: EBN was double-boiled for an extended period, then digested with gastric enzymes to extract active peptides. Digestion was over 90% efficient, and peptide molecular weights were measured. The enzymatic digest was then fractionated using an activity-guided approach based on assays for skin moisturization and anti-inflammatory properties. Results: A novel bioactive heptapeptide, with the sequence LAGAAHF and designated EBNP3, was identified and characterized. It attenuated TNF-α-induced inflammatory responses in HaCaT keratinocytes and alleviated dermatitis symptoms in a DNCB-induced C57BL/6 mouse model. Conclusions: EBN-derived peptides with skin moisturizing and anti-inflammatory activities hold significant promise for development into functional ingredients for skincare products.
Source: Pharmaceuticals
DOI: 10.3390/ph19040649
Institution: Hong Kong University of Science and Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funders: University Grants Committee, Guangdong Science and Technology Department, Science, Technology and Innovation Commission of Shenzhen Municipality, Foshan University, Shenzhen Municipal Science and Technology Innovation Council, Zhongshan Science and Technology Bureau, Health and Medical Research Fund
Awards: G1350236218, G1383580875, G1523434030, G1682068844, G180627948, G1822215872, G1882891083, G2749288639, G2847992662, G2936606030, G3029709747, G3752479216, G3961407263, G4252278179, G4453878098, G4767787907, G4921114337, G565207721, G566364576, G5690131637, G5902451608, G6092626974, G6247802227, G6251552351, G6659294118, G743643137, G7479245602, G764820638, G7924112240, G7943768837, G8230769053, G8387555400, G8452135572, G8682221018, G8745380674, G8863617296
OpenAlex ID: W7155208602
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