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Novel Pyrido[4,3- d ]pyrimidine Derivatives as Kirsten Rat Sarcoma (KRAS) G12C Potential Inhibitors

Year: 2026

Type: editorial

Abstract: High Resolution Image Download MS PowerPoint Slide This highlight describes novel substituted 2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3- d ]pyrimidine derivatives as potential inhibitors for Kirsten Rat Sarcoma (KRAS) G12C, which is extensively expressed across a variety of cancers. The patent provides detailed description of the preparation routes, methods of use, biological activity evaluations, and pharmaceutical compositions.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00190

Authors: Ruihu Song, Steven H. Liang

Institutions: Emory University, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7155222111

Cites: 7

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