Work

Prenylated acylphloroglucinols from the fruits of Hypericum patulum

Year: 2026

Type: article

Abstract: Twenty-eight prenylated acylphloroglucinols, including the new hypulatones C–F ( 1 – 4 ), have been isolated from the fruits of Hypericum patulum and structurally characterized. Compound 1 represents a rare meroterpenoid formed through the addition of a prenylated acylphloroglucinol unit and a sesquiterpenoid moiety. Spirocyclic polycyclic polyprenylated acylphloroglucinol 2 contains six chiral centers, and its relative configuration was established based on 1 H– 1 H coupling constants, conformational analysis, and NOE correlations. The cytotoxic activities of all isolates against two human carcinoma cell lines (Huh-7 and Panc-1) were evaluated using the CCK-8 assay. Bioassay results indicated that compounds 6 , 8 , and 15 exhibited moderate antiproliferative activity. Graphical Abstract

Source: Natural Products and Bioprospecting

DOI: 10.1007/s13659-026-00629-9

Authors: Yu-Feng Qiu, Yi Zhou, Cheng Chen, Juan Huang, Xing-Wei Yang

Institutions: Sun Yat-sen University, Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Natural Compound Pharmacology Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Natural Science Foundation of Guangxi Province, High-level Hospital Construction Project of Guangdong Provincial People's Hospital