Work

Connectivity-guided transcranial magnetic stimulation of the dopamine system: A proof-of-concept study

Year: 2026

Type: article

Abstract: Dopamine plays an important role in many brain functions, including movement, reward and cognition. Abnormalities in dopamine function occur in brain disorders with symptoms dependent on the affected dopaminergic pathways. Although medications targeting the dopamine system can be highly effective, they lack pathway specificity, resulting in adverse effects via modulation of other dopaminergic pathways. These undesirable effects due to the lack of network-specific dopaminergic modulation are exacerbated by varying optimal dopaminergic tone across brain networks.

Source: Brain stimulation

DOI: 10.1016/j.brs.2026.103109

Authors: Mikael Eklund, Mark C. Eldaief, Lauri Tuominen, Kalle J. Niemi, Juho Aaltonen, Virva Saunavaara, Jussi Hirvonen, Semi Helin, Christin Y. Sander, Bruce Rosen, Alvaro Pascual-Leone, Michael D. Fox, Aapo Nummenmaa, Juho Joutsa

Institutions: University of Turku, Turku University Hospital, Harvard University, Massachusetts General Hospital, Royal Ottawa Mental Health Centre, Institute of Mental Health Research, Turku PET Centre, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology, Hebrew SeniorLife, Brigham and Women's Hospital

Language: English

Topic: Transcranial Magnetic Stimulation Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,430

Funders: Suomen Lääketieteen Säätiö, Academy of Finland, Sigrid Juséliuksen Säätiö, Orionin Tutkimussäätiö, Suomen Aivosäätiö, Maire Taposen Säätiö, Turun Yliopistollinen Keskussairaala, National Institutes of Health

OpenAlex ID: W7155415616

FWCI:

Cites: 10

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Related to: 10