The generation of antibody diversity. I. Studies on the population distribution of anti-DNP antibody affinities and on the influence of allotype on antibody affinity and concentration.
Year: 1973
Type: article
Abstract: A genetically diverse population of sixty-four rabbits has been studied with respect to the concentration and affinity of anti-DNP antibody produced over the course of a year following a single injection of DNP-BGG. It was found that the responses of male and female members of the population were essentially identical throughout the entire course of the immune response. The effect of allotype on the concentration and affinity of the antibody produced was examined. It was observed that the b6 allotype was associated with the production of decreased concentrations of antibody, the b5 allotype with the production of increased concentrations of antibody, the a1 allotype with the production of high affinity antibody and the a2 allotype with the production of low affinity antibody when compared to the remainder of the population. A tendency was also seen for individuals to maintain, over the course of time, their relative position in the population with respect to the concentration and affinity of the antibody they produce. Finally, it was observed that the mean affinity of the population continually shifted towards high affinity over the period of observation and that the standard deviation of the population with regard to the affinity of the antibody produced decreased with time.
Source: PubMed Central
Authors: T P Werblin, Y T Kim, R Mage, B Benacerraf, G W Siskind
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W71554476