Sertraline-Associated Microscopic Colitis Flare in Pregnancy
Year: 2026
Type: article
Study design: Case Report
Abstract: Microscopic colitis (MC) is a histologically confirmed cause of chronic diarrhea with normal endoscopy, and limited data complicate diagnosis and management during pregnancy. We report a 31-year-old woman with lymphocytic colitis, initially misdiagnosed as irritable bowel syndrome, who experienced an MC flare at 15 weeks' gestation after starting sertraline. Symptoms resolved with sertraline discontinuation and budesonide, with remission maintained postpartum. This case underscores the importance of medication review, early recognition, and multidisciplinary care in pregnant patients with persistent diarrhea, particularly when coordinating gastrointestinal and psychiatric management.
Source: ACG Case Reports Journal
Institutions: Beth Israel Deaconess Medical Center, Harvard University
Language: English
Topic: Microscopic Colitis
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7155547740