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Acquired Angioedema Associated With Systemic Lupus Erythematosus Presenting as Acute Abdomen: A Case Report

Year: 2026

Type: article

Abstract: Acquired angioedema (AAE) due to C1 inhibitor deficiency can present as acute abdomen. A 24-year-old woman developed severe abdominal pain and bowel wall edema initially suggestive of hereditary angioedema, but genetic testing excluded it. She later manifested fever, arthritis, rash, and serological abnormalities consistent with systemic lupus erythematosus (SLE). SLE-associated AAE was diagnosed, and immunosuppressive therapy led to clinical and biochemical improvement. This case highlights the importance of considering AAE in patients with unexplained abdominal pain and hypocomplementemia to avoid misdiagnosis and unnecessary surgical intervention.

Source: Journal of General and Family Medicine

DOI: 10.1002/jgf2.70116

Authors: Seiji Shiota, Shogo Kodama, Kouichirou Tahara

Institution: Oita University

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,600