Work

Dynamic GTPase networks reshaping endosomal organelle identities

Year: 2026

Type: review

Abstract: Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemically distinct subdomains. Their dynamic localization reshapes organelle identities, making it difficult to classify endosomes into rigid categories. In this review, we provide an overview of the functional diversity of endosomal organelles in the context of recent discoveries, highlighting the dynamic role of small GTPases in the organization of cargo trafficking and cargo identity. We suggest that a framework centred on functional subdomains coordinated by ARF and RAB GTPase networks provides an informed perspective on the organisation of endocytic and secretory systems and their crosstalk.

Source: Current Opinion in Cell Biology

DOI: 10.1016/j.ceb.2026.102644

Authors: David C. Gershlick, Francesca Bottanelli

Institutions: University of Cambridge, Freie Universität Berlin

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funders: Wellcome Trust, Deutsche Forschungsgemeinschaft, Biotechnology and Biological Sciences Research Council