Work

Early identification of persistent progressive myocardial injury in Duchenne muscular dystrophy: a prospective, single-center cohort study

Year: 2026

Type: article

Abstract: We aimed to clarify the different developmental processes of myocardial injury and their significance in Duchenne muscular dystrophy (DMD), and to optimize the long-term management of DMD-associated cardiomyopathy. A prospective, single-center cohort study of children with DMD was conducted between June 2023 and April 2025 at West China Second University Hospital. Clinical symptoms and heart function-related indicators were monitored in children aged > 7 years. Unpaired two-tailed Student’s t-test, Mann–Whitney U test, and chi-squared test were applied according to the data type and normality, and post hoc Bonferroni correction was performed among the intragroup factors. A total of 174 children with DMD were enrolled, 25.29% of whom had high cardiac troponin I (cTnI) levels (cTnI-H group), among whom 75% had cTnI elevations < 10-fold (cTnI-H1 subgroup), 15.91% had cTnI elevations > 10-fold but < 30-fold (cTnI-H2 subgroup), and 9.09% had cTnI elevations > 30-fold (cTnI-H3 subgroup). During follow-up, 15.38% of the children in the normal cTnI level group (cTnI-N group) had newly elevated cTnI levels, whereas the elevated cTnI levels in the cTnI-H group had decreased to normal in 9.09% of the children, exhibited repeated elevations in 33.33% of the children, had continuous elevations in 57.58% of the children. 100% of the children in the cTnI-H3 subgroup had newer or expanded late gadolinium enhancement (LGE) and perfusion defects on cardiac magnetic resonance (CMR). The longest duration of elevated cTnI was 15 months, in which 100% had newer or expanded LGE and perfusion defects on CMR. There might be three different states of myocardial injury in DMD according to the degree of cTnI elevation, and the outcomes of elevated cTnI levels and CMR: transient injury, fluctuating injury, and persistent progressive injury. These three states might alternate and fluctuate with each other. The significant increase and long duration of elevated cTnI levels might be associated with persistent progressive myocardial damage. Regular monitoring (once a month for elevated cTnI levels) of cTnI levels might help identify persistent progressive myocardial damage at an early stage and optimize the long-term management of DMD-associated cardiomyopathy.

Source: Scientific Reports

DOI: 10.1038/s41598-026-46507-9