Design, Synthesis, and Structural Analysis of Binaphthyl‐Based Chiral Benzindenes
Year: 2026
Type: article
Abstract: Chiral benzindenes are an unexplored structural motif in the realm of organic synthesis. This is a result of a lack of synthetic protocols for constructing these compounds in which chirality does not arise from additional chiral substituents. This work introduces an unprecedented route toward chiral benzindenes as a new potential structural motif for further exploratory studies. Starting from readily available ( R )‐BINOL, the convergent synthesis over 9 steps culminated in benzindene with embedded chirality into the binaphthyl framework. The synthetic challenges associated with structural decoration are addressed and evaluated, while DFT and NMR structural analysis of the prepared chiral benzindene revealed its molecular characteristics.
Source: Advanced Synthesis & Catalysis
DOI: 10.1002/adsc.70478
Authors: Marko Gobin, Nikola Topolovčan
Institution: Ruđer Bošković Institute
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
OpenAlex ID: W7155606436