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From daily burden to scheduled protection: the “vaccine-like” shift in hypertension

Year: 2026

Type: article

Abstract: Global hypertension control remains stagnant due to the fragility of daily medication adherence rather than a lack of effective drugs. Long-acting siRNA therapies offer a “vaccine-like” paradigm shift, transferring responsibility from the patient’s daily memory to the health system’s reliability. This approach introduces “pharmacological moral hazard,” where patients may neglect lifestyle modifications under a false sense of total security. Realizing the promise of democratized protection requires redesigning care pathways to ensure that infrequent dosing does not lead to clinical disengagement.

Source: Journal of Human Hypertension

DOI: 10.1038/s41371-026-01149-2