CAR immune cell therapy strategies and advances for lung cancer
Year: 2026
Type: article
Abstract: Lung cancer, characterized by its high heterogeneity, propensity for metastasis, and insidious progression, stands as one of the most prevalent lethal malignancies worldwide. Current therapeutic approaches encompass surgical resection, radiotherapy, chemotherapy, and targeted therapy, with immune checkpoint inhibitor-based immunotherapy now established as one of the standard treatment modalities. Furthermore, novel immunotherapeutic strategies are under investigation for lung cancer treatment. Chimeric antigen receptor (CAR) immune cell therapy, an adoptive cell therapy, has demonstrated effective pathological cell clearance and manageable safety profiles across various diseases including cancers, autoimmune disorders, and infections. This review summarizes preclinical and clinical advancements in CAR-engineered immune cells for lung cancer treatment, highlighting enhancement strategies explored by researchers to achieve effective CAR-T therapy, as well as the research status of CAR-NK and CAR-Macrophage (CAR-M), and emphasizing emerging therapeutic opportunities to improve survival outcomes in lung cancer patients through CAR-based adoptive cell therapies.
Source: Discover Oncology
Authors: Song Zheng, Yingying Chen, Ruilin Li, Song Peng
Institutions: Anhui Medical University, Hefei First People's Hospital
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,690
Funder: Anhui Medical University
OpenAlex ID: W7155622364