Work

Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors

Year: 2026

Type: article

Abstract: • Dual 2B4·4-1BB signaling reprograms HER2-CAR NK-92 cells for durable antitumor power • Synergistic costimulation drives deep infiltration of mAbs resistant tumor spheroids • Dual 2B4·4-1BB CAR NK-92 therapy achieves long-lasting tumor remission • This next-generation CAR-NK design overcomes immune and TME derived resistance

Source: Cancer Letters

DOI: 10.1016/j.canlet.2026.218534

Authors: Bence Gergely, Márk Vereb, István Rebenku, Árpád Szöőr, György Vereb

Institution: University of Debrecen

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,960