Work

Y-box binding protein-1 at the crossroads of DNA damage response and tumor immune evasion

Year: 2026

Type: article

Abstract: Tumor response to radiotherapy is shaped by multiple factors including immune modulation, tumor microenvironment, and genetic factors. Among these, the Y-box binding protein-1 is a multifunctional DNA and RNA-binding protein frequently overexpressed in tumors. Y-box binding protein-1 controls the activation of DNA damage response signaling following radiotherapy. Emerging evidence suggests that the role of Y-box binding protein-1 extends beyond DNA damage response regulation to shaping tumor-immune interactions by regulating cytokine production, promoting immune evasion, and altering immune checkpoint expression. Elucidating these immune-related functions of Y-box binding protein-1 may uncover novel mechanisms of tumor immune evasion and identify novel therapeutic targets to enhance cancer immunotherapy. This minireview summarizes current insights into the role of Y-box binding protein-1 in immune regulation, highlighting its impact on tumor immunity and potential clinical applications.

Source: JNCI Cancer Spectrum

DOI: 10.1093/jncics/pkag044

Authors: Mahmoud Toulany, Quaovi H Sodji

Institutions: University of Wisconsin–Madison, University of Wisconsin Carbone Cancer Center, William S. Middleton Memorial Veterans Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,050