Work

Early Calciphylaxis Mimicking Infection in a Patient With End‐Stage Renal Disease and Sarcoidosis: A Diagnostic and Wound Management Challenge

Year: 2026

Type: article

Abstract: Calciphylaxis is a rare, life-threatening disorder primarily affecting patients with end-stage renal disease (ESRD) on dialysis. Early lesions can mimic infection, leading to delays in diagnosis and wound-directed care. We describe an atypical early presentation of calciphylaxis in a patient with ESRD and sarcoidosis, initially misdiagnosed as cellulitis. Despite early sodium thiosulfate therapy and metabolic control, the patient developed progressive necrotic wounds. This case underscores that calciphylaxis can progress despite controlled mineral metabolism and standard therapy, particularly when potentiated by conditions like sarcoidosis. Early dermatologic evaluation and a high index of suspicion are critical to avoid misdiagnosis.

Source: International Wound Journal

DOI: 10.1111/iwj.70928

Authors: Nicole Nowak, Aashna Farishta, Rachel Chang, Wanna Zhang

Institution: Rush University Medical Center

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,580