Work

Identification of hsa-miR-144-3p as a novel immunotherapeutic target for glioblastoma based on disulfidptosis-related analysis

Year: 2026

Type: article

Abstract: BACKGROUND: There is no relevant research on the effect of disulfidptosis-related microRNA (miRNA) on the immune microenvironment in glioblastoma (GBM). METHOD: We integrated transcriptomic data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas(CGGA) databases to comprehensively identify disulfidptosis-related miRNAs in GBM and evaluated their functional pathways and immunological relevance using bioinformatics approaches. RESULT: We identified hsa-miR-144-3p as a key disulfidptosis-related miRNA significantly associated with GBM. Functional analyses revealed that miR-144-3p was markedly enriched in immune-related pathways and strongly correlated with stromal score, immune score, and tumor purity. Moreover, its expression was significantly associated with immune checkpoint expression and immune cell infiltration patterns, suggesting a pivotal role in modulating the tumor immune microenvironment. CONCLUSIONS: This study reveals that the disulfide-related gene miR-144-3p, as a potential key miRNA may improve the prognosis by regulating immune cell infiltration and promoting the expression of immune checkpoints in GBM and serve as a target in GBM treatment. Our findings also provide new insights into the mechanism of disulfidptosis in GBM.

Source: Discover Oncology

DOI: 10.1007/s12672-026-05048-3