AutoDRY: a genome-wide resource revealing phase-specific control of autophagy activation, amplitude, and termination
Year: 2026
Type: article
Abstract: Despite decades of research identifying the core autophagy-related (ATG) gene products that execute macroautophagy (hereafter autophagy), a systems-level understanding of how the broader genome dynamically tunes this process remains limited. Most studies rely on bulk assays that capture cumulative degradation at a single time point, making it difficult to resolve how autophagy is activated, sustained, and terminated over time. In addition, approaches to quantify temporal response kinetics across thousands of genotypes in parallel at the population level have been lacking, hindering predictive modeling and the development of precise pharmacological strategies to modulate autophagy.
Source: Autophagy
Authors: Jorrit M. Enserink, Nathalia Chica
Institution: University of Oslo
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Kreftforeningen, Norges Forskningsråd
OpenAlex ID: W7155708100