Year: 2026
Type: article
Study design: Case Report
Abstract: Glioblastoma multiforme (GBM) is an aggressive primary brain tumour with a high recurrence despite multimodal therapy. Magnetic resonance imaging done after treatment can be limited by radiation necrosis, while F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) suffers from high cortical background activity. We present the case of recurrent GBM in which Ga-68 Fibroblast Activation Protein Inhibitor (FAPI) PET/CT demonstrated intense uptake with higher tumour-to-background contrast compared with FDG PET/CT. This case demonstrates the diagnostic potential of FAPI imaging in recurrent GBM and highlights its emerging theranostic relevance as a biomarker for FAPI-targeted radionuclide therapy.
DOI: 10.25259/ijnm_146_25
Institution: All India Institute of Medical Sciences
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7155952356