Work

A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor

Year: 2026

Type: article

Abstract: Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double hydroxide (CaGd-LDH), a novel nanoradiosensitizer combining gadolinium (Gd) and calcium (Ca 2+ ) in a layered double hydroxide (LDH) structure. This design enables dual therapeutic functionalities to realize high Z element Gd-mediated radiosensitization and pH-responsive Ca 2+ release to trigger pyroptosis-induced immunotherapy, addressing both local tumor control and metastatic spread in breast cancer bone lesions. In vitro, it induces reactive oxygen species production, DNA damage, and pyroptosis via caspase-1/GSDMD pathway activation, which can significantly suppresses breast cancer cell proliferation. In vivo, CaGd-LDH combined with X-ray irradiation inhibits tumor growth, reduces cell proliferation, activates pyroptosis, and suppresses lung metastasis in a breast cancer bone metastasis mouse model. This multifunctional CaGd-LDH integrates radiosensitization, pyroptosis induction, and good biocompatibility, offering a promising strategy to improve local therapy and inhibit distant metastasis in breast cancer bone metastasis.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2026.103165