Year: 2026
Type: article
Abstract: Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential. In this paper, the authors review how the circular RNA Cdr1as and its interacting non-coding RNAs regulate neuronal stress responses and synaptic activity, highlighting general principles of RNA-based regulatory mechanisms and their relevance for brain function, disease, and therapy.
Source: Nature Communications
Institutions: Max Delbrück Center, Universitat Pompeu Fabra, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Aarhus University, German Centre for Cardiovascular Research, Deutsches Konsortium für Translationale Krebsforschung, NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
OpenAlex ID: W7156200212