Year: 2026
Type: article
Study design: Case Report
Abstract: Verrucous carcinoma of the larynx is a rare, well-differentiated variant of squamous cell carcinoma that is locally invasive but rarely metastasizes. However, diagnosis can be difficult because superficial biopsies often fail to demonstrate the characteristic pushing border of verrucous carcinoma. Consequently, multiple biopsies may fail to establish a definitive diagnosis. Surgical excision remains the primary treatment. We present a case of a 54-year-old man who required several years to achieve a definitive diagnosis of verrucous carcinoma and whose lesion recurred repeatedly despite multiple excisions. This case emphasizes the importance of obtaining adequately deep and wide biopsy specimens for the accurate diagnosis of verrucous carcinoma. It also illustrates the therapeutic dilemma in the management of glottic verrucous carcinoma, as aggressive excision may compromise vocal function, whereas conservative excision increases the risk of recurrence.
Authors: Minah Shin, Wonae Lee, Sang Joon Lee
Institutions: Dankook University Hospital, Dankook University
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7156260717
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