Work

Generation of an induced pluripotent stem cell line (KCGMHi001-A) from a patient with CEP85L related posterior predominant lissencephaly (LIS10)

Year: 2026

Type: article

Abstract: Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals exhibit a range of developmental delays, including intellectual disability, language impairment, and frequently intractable epilepsy. LIS10 results from pathogenic variants in the centrosomal gene CEP85L. Peripheral blood mononuclear cells obtained from a LIS10 patient were reprogrammed into induced pluripotent stem cells (iPSC; line KCGMHi001-A) using Sendai virus. This iPSC model serves as a valuable resource for future mechanistic studies and therapeutic development for LIS10.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.104004

Authors: Pei-Shan Hou, Sheng-Jye Lim, Huai-En Lu, Meng-Han Tsai

Institutions: National Yang Ming Chiao Tung University, National Sun Yat-sen University, Chang Gung University, Kaohsiung Chang Gung Memorial Hospital

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360