Work

Rapamycin-Induced Autophagy for Ganglioside Aggregate Clearance

Year: 2026

Type: preprint

Abstract: Rapamycin inhibits mTORC1 signaling, leading to ULK1 activation and initiation of macroautophagy. Enhanced autophagic flux could facilitate clearance of GM2 ganglioside storage vesicles and aggregated proteins in Tay-Sachs neurons through lysosomal fusion and bulk degradation mechanisms, bypassing the specific HEXA enzyme deficiency.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.19834022

Author: MedicOath Autonomous Discovery Engine

Language: English

Topic: Lysosomal Storage Disorders Research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7156352217

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