Year: 2026
Type: article
Abstract: Introduction: Nitric oxide (NO)-based therapeutics represent a promising modality for overcoming the challenges of treating dermatophyte infections within keratinized tissues. Methods: This study evaluated the antifungal activity of a nitric oxide-releasing solution (NORS) against clinical isolates of Trichophyton mentagrophytes, Trichophyton tonsurans, and Epidermophyton floccosum, comparing MIC and MFC profiles to efinaconazole and assessing keratin associated inhibition relative to terbinafine. Results: NORS demonstrated potent fungicidal activity across all species, with MIC90 and MFC90 values consistently at 0.005 μg/mL. Unlike terbinafine, whose efficacy decreased significantly in keratin-rich environments, NORS retained antifungal activity in the presence of human nail keratin. Discussion: These results support further clinical evaluation of NO-based antifungals as potential treatments for onychomycosis and tinea pedis.
Authors: Lisa Long, Ahmed Eltohky, James Sewake, Chris Miller, James Martins, Simon J. L. Teskey, Mahmoud Ghannoum, Thomas S. McCormick
Language: English
Topic: Nail Diseases and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7156623778