Hypoglycemic and Diuretic Effects of Hibiscus sabdariffa Calyx and Flower in Wistar Rats: An Integrative Review of Preclinical Evidence
Year: 2026
Type: article
Abstract: Preclinical research over the last decade has repeatedly shown that Hibiscus sabdariffa offers meaningful biological effects that touch two important aspects of metabolic health: blood sugar control and kidney function. Studies using Wistar rats reveal that both the calyx and flower extracts help lower glucose levels, improve the way the body handles insulin, and calm oxidative and inflammatory stress two drivers of metabolic dysfunction. At the same time, the plant acts as a natural diuretic, gently increasing urine output and supporting renal filtration without the harsh electrolyte loss seen in synthetic drugs. These benefits appear to stem from a rich mix of anthocyanins, hibiscus acid, organic acids, and flavonoids that work together rather than individually. However, the existing evidence is uneven; researchers often use different extraction approaches, doses, and animal models, making it difficult to compare results across studies. Moving forward, clearer standardization, stronger pharmacokinetic data, and carefully planned clinical research will be necessary to understand how these promising preclinical findings may translate into human therapies.
Institution: CT University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7156779005