Year: 2026
Type: article
Abstract: L-serine is an amino acid involved in maintaining intestinal mucosal homeostasis through its role in protein synthesis but also in redox balance, immune function and lipid metabolism. It also contributes to mucus production, the epithelial barrier integrity and gut microbiota composition. Prokaryotic cells, including Escherichia coli, have developed mechanisms to exploit L-serine to support their growth, virulence, inflammatory and/or carcinogenic properties. In this review, we summarize current findings on L-serine metabolism in the intestinal mucosal homeostasis, its interactions with microbiota, and its modulation in digestive diseases. Finally, we highlight directions for future research to target L-serine as a promising therapy.
Source: Communications Biology
Institutions: Inserm, Université Clermont Auvergne, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Microbe, Intestine, Inflammation and Host Susceptibility, Centre National de la Recherche Scientifique, Université de Poitiers, Écologie et Biologie des Interactions
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W7156941100