Work

Double filtration plasmapheresis in antithyroid drug-refractory Graves disease with a massive goiter

Year: 2026

Type: article

Abstract: We report a case of double filtration plasmapheresis (DFPP) performed in medication-resistant Graves disease (GD) with a massive goiter. A 19-year-old female was diagnosed with GD and initially demonstrated poor medication compliance. She presented with loss of consciousness from hypoxemia due to goiter-related tracheal narrowing. Despite inpatient drug therapy, the thyroid hormone levels remained high. We performed DFPP to control thyrotoxicosis before proceeding with thyroidectomy. After 4 sessions, thyroid hormone levels improved, enabling total thyroidectomy. GD with a large goiter may be refractory to medical therapy. In such cases, DFPP can improve thyroid hormone levels.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luag095

Authors: Miku Yamazaki, Hiroyuki Uchinuma, Yuka Yokota, Hiroki Ishii, Takeshi Moriguchi, Kyoichiro Tsuchiya

Institutions: University of Yamanashi Hospital, University of Yamanashi

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930