Sex Differences in the Treatment of People with Parkinson’s Disease with a Device-Aided Therapy: A Prospective Real-World Study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background and Objective: Sex differences in the treatment of people with Parkinson’s disease (PwP) with a device-aided therapy (DAT) have been poorly investigated. Our aim was to analyze sex differences in the management and response to a DAT in PwP in daily clinical practice (DCP). Patients and Methods: Data collected in the DATs-PD GETM Spanish Registry until 30 October 2025 were used. This is a descriptive, observational, prospective, and multicenter clinical registry with progressive inclusion of PwP treated with a DAT in DCP conditions in more than 40 centers from Spain. Sex differences in the DAT received and changes in quality of life (QoL), motor symptoms (MS), non-motor symptoms (NMS), and autonomy for activities of daily living (AADL) after 6 months of treatment were analyzed. Results: A total of 618 PD patients (66.9 ± 9.5 years old; 57.6% men) were treated with a DAT. A significant difference was observed in the DAT type according to sex (p = 0.006), with 73.1% of PwP who were treated with deep brain stimulation being men. At the time of DAT indication, women were older, received a higher levodopa equivalent daily dose, and had a worse health-related QoL and AADL. OFF time decreased, whereas MS and NMS burden and health-related QoL improved at 6 months follow-up in both groups (men and women). AADL improved only in men during the OFF state. Conclusion: Sex differences were detected in the use of DATs in PwP. Improvement in OFF time, MS, NMS, and QoL was detected in both groups.
Source: Medical Sciences
Authors: Diego Santos García, Ángela Solleiro Vidal, Marta Blázquez Estrada, Pablo Mir, Nuria López Ariztegui, Déborah Alonso Modino, Inés Legarda, Alejandro Peral, Rocío García-Ramos, Iria Cabo, Pilar Sánchez Alonso, Jorge Hernández-Vara, Javier Ruíz Martínez, María Álvarez Sauco, Gustavo Fernández-Pajarín, Lydia Vela, Francisco Escamilla Sevilla, Jesús Ramírez Sánchez-Ajofrin, Débora M. Cerdán Santacruz, Guillermo González Ortega, DATs-PD GETM Spanish Registry Group DATs-PD GETM Spanish Registry Group
Institutions: Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña, Hospital Universitario Central de Asturias, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Hospital Universitario de Toledo, Hospital Universitario Nuestra Señora de Candelaria, Hospital Universitario Son Espases, Hospital de Sant Joan Despí Moisès Broggi, Hospital Clínico San Carlos, Complejo Hospitalario de Pontevedra, Hospital Universitario Puerta de Hierro Majadahonda, Vall d'Hebron Hospital Universitari, Donostiako Unibertsitate Ospitalea, Hospital General Universitario de Elche, Complejo Hospitalario Universitario de Santiago, Hospital Universitario Fundación Alcorcón, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario Virgen de las Nieves, Hospital Universitario 12 De Octubre, Hospital General De Segovia, Hospital Universitario de Móstoles
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,689
OpenAlex ID: W7156947904
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