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1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

Year: 2026

Type: article

Abstract: 1,1‐Disubstituted vinyl bromides have emerged as powerful and versatile building blocks for the synthesis of nitrogen‐containing heterocycles. Their dual functionality—encompassing both a reactive bromide and a polarized CC bond—enables diverse transformations including cycloadditions, metal‐catalyzed couplings, lithiation, and radical or cascade processes. This review summarizes recent advances up to 2025 in the preparation of aziridines, pyrroles, indoles, indolizines, pyrrolidines, pyrazoles, triazoles, isoxazoles, isoxazolidines, and piperidines derived from these substrates. Particular attention is given to regio‐ and stereoselective strategies, the construction of fluorinated and functionalized heterocycles, and applications in medicinal chemistry.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202501199

Authors: Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal

Institutions: Centre National de la Recherche Scientifique, Chimie ParisTech - PSL, Université Paris Sciences et Lettres, Institute of Chemistry for Life and Health Sciences

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

OpenAlex ID: W7156971303

FWCI:

Cites: 188

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