miR-3678-3p Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating Phosphatase and Tensin Homolog
Year: 2026
Type: article
Abstract: Background/Aims: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy characterized by high invasiveness. The current study aimed to evaluate the role of miR-3678-3p in ESCC and its potential mechanisms. Materials and Methods: The study included 109 ESCC patients. The miR-3678-3p expression in ESCC tissues and cells was quantified. The association between miR-3678-3p and ESCC severity and adverse prognosis was evaluated. The target relationship between miR- 3678-3p, phosphatase and tensin homolog (PTEN) was confirmed. The effects of miR 3678-3p and PTEN on ESCC cell function were analyzed. Results: ESCC tissues and cells exhibited elevated expression of miR-3678-3p. Elevated miR-3678-3p expression was significantly associated with malignant clinical features in ESCC, including larger tumor size, advanced tumor-node-metastasis staging, higher lymph node metastasis, and poor tumor differentiation. High miR-3678-3p expression served as a predictor of shorter overall survival. miR-3678-3p targeted and regulated PTEN. miR-3678-3p knockdown significantly suppressed the malignant progression of ESCC cells, whereas silencing of PTEN reversed these effects. miR-3678-3p and PTEN jointly participated in the development of ESCC. Conclusion: miR-3678-3p serves as a promising prognostic marker for predicting the severity and adverse outcomes of ESCC. miR- 3678-3p promotes ESCC progression by targeting PTEN.
Authors: Jinjun Zhang, Ci Cheng, Taiyu Li
Institution: Tianjin University of Traditional Chinese Medicine
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7157214557
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