Development of Biphenyl-Substituted Uracil-Based Hydroxamic Acids (UBHAs) as Potent HDAC Inhibitors with Pro-Apoptotic Activity in Leukemia and Prostate Cancer Cells
Year: 2026
Type: article
Abstract: cell proliferation, enhanced histone and tubulin acetylation, upregulated p21, and downregulated Bcl-2. These findings identify biphenyl-substituted UBHAs as promising therapeutics and probes to dissect HDAC biology.
Source: Journal of Medicinal Chemistry
Authors: Francesco Fiorentino, Giulio Bontempi, Federica Michetti, Valeria Pecci, Emanuele Fabbrizi, Daniela Passeri, Letizia Corsetti, Valentina Farini, Fabrizio Casano, Antimo Gioiello, Antonella Di Sotto, Roberto Pellicciari, Donatella Del Bufalo, Daniela Trisciuoglio, Simona Nanni, Raffaele Strippoli, Antonello Mai, Dante Rotili
Institutions: Sapienza University of Rome, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Università Cattolica del Sacro Cuore, Instituto Nazionale Tumori Regina Elena, University of Perugia, Institute of Molecular Biology and Pathology, National Research Council, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Roma Tre University, Istituto Nazionale Biostrutture e Biosistemi
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7158600696