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The Role of Probiotics in the Prevention and Complementary Treatment of Colorectal Cancer. Part 1

Year: 2026

Type: article

Abstract: Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies globally, with a concerning rise in incidence among younger populations. This article, the first of a two-part series, explores the pathophysiology of CRC, focusing on the adenoma-carcinoma sequence and the anatomical factors influencing disease progression. Central to this discussion is the human gut microbiota—a complex "new organ" essential for metabolic and immunological homeosta-sis. We examine how environmental factors, genetics, and lifestyle choices lead to dysbiosis, a microbial imbalance that fosters chronic inflammation and carcinogenesis. By reviewing the spatial distribution of bacterial phyla and the transition from a healthy to a pathogenic state, this paper establishes the microbiological foundation necessary to understand CRC development and the potential for targeted microbial interventions.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.19916571

Authors: Alves, Teresa Margarida, Pereira, Henrique De Magalhães

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7158605644

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