Management of lower urinary tract symptoms before prostate cancer radiotherapy: a call for innovative strategies
Year: 2026
Type: article
Abstract: Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms (LUTS) in aging men. As the incidence of prostate cancer (PCa) increases with age, coexistence of BPO and PCa is a frequent issue. Radical prostatectomy might be considered as the best option for patients presenting with severe obstructive symptoms, allowing to simultaneously treat both diseases. However, not all patients are eligible or prefer surgery, therefore a large number of patients are referred to receive PCa radiotherapy (RT). Preexisting LUTS represent a well-known risk factor to develop severe genito-urinary (GU) toxicity. While improving urinary function before starting irradiation appears to be crucial, the development of new minimally invasive surgical therapies (MIST) for BPH creates new opportunities for treatment personalization in RT patients with LUTS.
Source: World Journal of Urology
Institutions: Université de Tours, Centre Hospitalier Universitaire de Tours, Université Paris Cité, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Inserm, Institut Necker Enfants Malades, Hôpital Européen Georges-Pompidou, St. Antonius Ziekenhuis, Cleveland Clinic, University of Bologna, Comprehensive Cancer Center Vienna, University College London, Medical University of Vienna, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Paris Cardiovascular Research Center, WSB University, Medical University of Silesia
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
OpenAlex ID: W7158682617