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Proarrhythmic Risk Assessment of Sildenafil under High-Dose Misuse Conditions Using the Comprehensive In Vitro Proarrhythmia Assay (CiPA)

Year: 2026

Type: article

Abstract: . Despite low in silico TdP predictions, functional assays suggest that high concentrations of sildenafil as in misuse may pose a clinically relevant risk of QT prolongation and arrhythmia.

Source: Biomolecules & Therapeutics

DOI: 10.4062/biomolther.2025.097

Authors: Hanbi Kim, Tae Woong Na, Inkyo Jung, Minji Kang, Sujeong Park, Chan Hyeok Kwon, Kikyung Jung

Institutions: Ministry of Food and Drug Safety, National Institute of Food and Drug Safety Evaluation

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Ministry of Food and Drug Safety

Award: G7492501504

OpenAlex ID: W7158797525

FWCI:

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